Overview

Country(s): Austria, Belgium, France, Germany, Israel, Italy, Netherlands, Norway, Slovakia, Slovenia, Spain,

Deadline: 17-03-2017 17:00 CET (pre-proposals)

Deadline:30-06-2017 (full proposals)

PROGRAMME SUMMARY

ERACoSysMed is a network of 15 funding organisations from 13 countries. The central aim of ERACoSysMed is to enhance the implementation of Systems Biology approaches in medical concepts, research and practice throughout Europe and Israel by structuring, coordinating and integrating national efforts and investments.

AIM OF JTC-2 CALL

The call aims to support the development of projects fostering the implementation of Systems Medicine approaches, in both, clinical research and medical practice, by funding a number of high quality research projects that will improve our current knowledge of human health and disease.

Systems Medicine is defined as the implementation of Systems Biology approaches in medical concepts, research and practice.

This involves iterative and reciprocal feedback between clinical investigations and practice with computational, statistical and mathematical multiscale analysis and modelling of pathogenetic mechanisms, disease progression and remission, disease spread and cure, treatment responses and adverse events as well as disease prevention both at the epidemiological and individual patient level. As an outcome Systems Medicine aims at a measurable improvement of patient health through systems-based approaches and practice.

Demonstrator projects should start with an idea or concept that addresses a clear medical or clinical need. It is expected that project outcomes will improve current knowledge of health and disease, leading to new paths for clinical research aimed at delivering better and more efficient and personalised prevention, diagnostics and treatments of human diseases.

Projects should within their envisaged duration, substantiate the translation of Systems Medicine into medical research and practice by focusing on high quality data sets and clinical relevance. Furthermore they should define new innovative approaches and tools that enable the integration of biological and clinical data that will lead to the creation of new and/or improved computational models. The added value to the Systems Medicine field should be demonstrated.

THEMATIC RESEARCH AREAS/ CHARACTERISTICS

Project proposals submitted under this call may include, but are not limited to, the following research areas/characteristics, as long as they fulfill the definition of Systems Medicine as laid out in the section ‘Aim of the Call’ above:

  • Understanding of disease complexity, early diagnosis of disease and the re-definition of disease phenotypes that will lead to better patient stratification.
  • Understanding the influence of differences like gender, age, ethnicity or other relevant data for the development and treatment of diseases at an individual level.
  • Investigation of shared common early pathways among diseases such as metabolism, immunology and cell proliferation to predict disease manifestation and progression.
  • Exploitation of the prognostic, diagnostic, preventive and therapeutic value of existing clinical material and data or, where relevant, appropriate models.
  • Refinement of experimental design and of prospective clinical data collection in newly set cohorts with the use of computational models that lead to a better understanding of the biological processes that play a fundamental role in complex diseases and identify key common underlying mechanisms.
  • Definition of a clear strategy to clinically validate the outcomes of the project, including the validation of the predictions of in silico computational models that will be developed using experimental and already available clinical datasets.
  • Proposals should provide clear evidence on how they expect to access appropriate, relevant and already available clinical material and associated data (patient cohorts with comprehensive clinical characterisation/annotation).

Note: Datasets for the proposed research areas should be already available before the implementation of the project. However, these datasets may be complemented and/or validated during the execution of the project.

DURATION, EVALUATION & FUNDING SPECIFICS

  • Projects can be funded for a period of up to three years and according to national funding organisations’ regulations.
  • Whilst applications will be submitted jointly by groups from several countries, individual groups will be funded by the individual ERACoSysMed funding organisation respective of the country from which applicants have applied. The applications are therefore subjected to eligibility criteria of individual funding organisations.
  • Thirteen funding organisations are involved in this call with a total budget of approximately 7.23 MEUR.
  • The FNR has allocated 300,000 EUR funding, which is expected to fund up to two projects.

APPLICATION INFORMATION

WHO CAN APPLY

Joint research proposals may be submitted by higher education institutions, non-university public research establishments, hospitals as well as commercial companies, in particular small and medium-size enterprises (SMEs), according to relevant national funding regulations.

Applicants are strongly advised to contact their national representative and confirm eligibility with their respective funding organisations in advance of submitting an application.

WHERE TO APPLY

Pre- and full proposals must be submitted to the ERACoSysMed submission platform by the given deadlines.

Additional documentation must be submitted the FNR no later than 5 working days after the ERACoSysMed deadlines. Submissions to the FNR must be done FNR Online Grant Management System.

ERACOSYSMED JTC-2 TIMELINE

  • Pre-proposal deadline: 17 March 2017, 17:00 CET
  • Invitation to submit full proposals: second half of May 2017
  • Full proposal deadline: 30 June 2017
  • Communication of evaluation results: October 2017
GENERAL APPLICATION CONDITIONS

Joint research proposals may be submitted by higher education institutions, non-university public research establishments, hospitals as well as commercial companies, in particular small and medium-size enterprises (SMEs), according to relevant national funding regulations.

Whilst applications will be submitted jointly by groups from several countries, individual groups will be funded by the individual ERACoSysMed funding organisation respective of the country from which applicants have applied. The applications are therefore subjected to eligibility criteria of individual funding organisations.

Applicants are strongly advised to contact their national representative and confirm eligibility with their respective funding organisations in advance of submitting an application.

NO MORE THAN TWO ELIGIBLE PARTNERS FROM SAME COUNTRY PER CONSORTIUM

Only transnational projects will be funded. Each consortium must involve a minimum of three and a maximum of five eligible partners from at least three different countries participating to the call (see list above). For reasons of transnational balance, in this call no more than two eligible partners from the same country are allowed to join each consortium.

COLLABORATORS NOT PARTICIPATING IN CALL CAN PARTICIPATE IN PROJECTS

External collaborators, i.e. groups from countries that are not participating in this call, or research groups from countries that are partners in this joint transnational call but do not ask for funding, may participate in projects, provided that they demonstrate in advance that their economic and human resources have already been secured (i.e. prior to the full-proposal submission) and will be available at the start of the project.

MAXIMUM NUMBER OF EXTERNAL COLLABORATORS & PARTNERS

The maximum number of external collaborators per consortium is two.

The maximum number of partners and external collaborators in each consortium should not exceed seven, i.e. three to five eligible partners, and a maximum of two external collaborators.

INCLUSION OF TEAMS FROM SLOVENIA & SLOVAKIA ENCOURAGED

In order to strengthen the implementation of Systems Medicine throughout Europe, the inclusion of research teams from Slovenia and Slovakia is encouraged. Therefore, consortia including partners from these two countries may increase the maximum number of eligible partners to seven or nine in cases involving two external collaborators.

CLINICAL EXPERTISE MANDATORY

Each transnational collaborative project should represent the critical mass to achieve the scientific goals, the translation of Systems Medicine approaches into medical research and practice, and to clearly demonstrate an added value from working together. Clinical expertise is mandatory in order to ensure an efficient transfer of results into clinical application.


Please note, the content of the call described in this pre-announcement may be subject to changes and is not legally binding to the funding organisations.

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