These post-conference proceedings are the collection of academic papers that were presented in the 22nd edition of the Benelux Conference on Artificial Intelligence (BNAIC). The BNAIC 2011 conference took place in Luxembourg on October 25-26, 2010 under the auspices of BNVKI-AIABN (Benelux Association for Artificial Intelligence), and the Dutch Research School for Information and Knowledge Systems (SIKS). The BNAIC conferences series was initiated in 1988 by the Netherlands Association for Artificial Intelligence (later incorporating Belgium and Luxembourg to become the Benelux Association for AI) in order to promote research in AI among Benelux AI researchers, scientists and engineers in related disciplines. BNAIC 2010 was the first time that this conference had been held in the Grand Duchy, which was only recently welcomed into the BNVKI fold. The conference was hosted jointly by the University of Luxembourg and the Centre de Recherche Public Henri Tudor. The proceedings include 66 peer-reviewed papers (29 full papers, 31 extended abstracts and 6 demonstrations).