Cardiovascular disease is a major preventable cause of death and accounts for significant healthcare costs worldwide. INFUSED will discover new candidate drugs for the treatment of myocardial infarction (MI). We will identify and rank compounds already approved for clinical use, which may activate the molecular interaction networks responsible for driving heart regeneration after MI. To accomplish this, we will: a. characterize dynamic interaction networks that are activated during (post-MI) heart regeneration in zebrafish, and b. identify drugs that can enhance the activity of such networks. The proposed drug repositioning strategy will mine and integrate information about candidate compounds from a wide spectrum of public and in-house generated “omic” resources. INFUSED will also exploit the predictive power of dynamic cellular-based models to enable the identification of potential targets and intervention strategies. We will validate top candidate targets and compounds on an in vivo model of MI in zebrafish.