Involvement of the immune system in Parkinson’s Disease

SCHEME: INTER Mobility

CALL: 2015

DOMAIN: BM - Life Sciences, Biology and Medicine

FIRST NAME: Tatiana

LAST NAME: Michel

INDUSTRY PARTNERSHIP / PPP: No

INDUSTRY / PPP PARTNER:

HOST INSTITUTION: LIH

KEYWORDS: Th2 immune cells; IL-13receptor; Neurturin; Parkinson's Disease; Dopaminergic neurons; Microglia; CD4+ T cells

START: 2016-08-01

END: 2017-07-31

WEBSITE: https://www.lih.lu

Submitted Abstract

The Department of Infection and Immunity (DII) is one of three research departments of the Luxembourg Institute of Health (LIH), which has recently been created by merging three formerly independent laboratories, headed by its inaugural director Professor Markus Ollert. The visiting research proposal Involvement of the Immune System in Parkinson’s Disease is part of the newly implemented research strategy of the DII, which is focused on molecular mechanisms of acute and chronic inflammation and the potential of therapeutic intervention through immunotherapy. Through her stay as a visiting scientist in the United States, the applicant aims to develop a novel focused research area in neuroimmunology within DII. This novel research focus is embedded into a long-term strategic research alliance in immune systems biology and neuroimmunology between DII-LIH and the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg. LCSB, which is headed by its founding director Professor Rudi Balling, has recently been awarded as National Centre of Excellence in Research on Parkinson’s disease (PD). The visiting researcher proposes to investigate the impact of the immune system in the initiation of the first stages of PD. To develop the necessary methodological background and the ideal strategy for this project, she proposes to join to The Scripps Research Institute (TSRI), La Jolla, in San Diego, which is one of the leading neuroscience research centres in the world. The hosting group of Professor Bruno Conti at the Department of Chemical Physiology is part of the Faculty of Molecular and Cellular Neuroscience of the University of California at San Diego and runs dedicated research programs with a special focus on PD.The objectives of this visiting research initiative comprise (i) Research actions, (ii) Capacity building and (iii) Institutional networking

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