In this proposal, we analyze the status quo of knowledge and technology transfer at the Luxembourg Centre for Systems Biomedicine (LCSB) and at the University of Luxembourg (UL), whilst the other interdisciplinary centre at the UL, the SnT, pursues a different strategy, following a mandate from the UL Board of Governors. We find that the basic function of IP detection and IP management are working reasonably well in view of the limited resources provided by central administration and at LCSB (approx. ½ FTE each). Not surprisingly, the tasks of scouting, marketing, and business development, which require more time and effort, are less well developed and would require substantial support. There is thus a clear need to develop these facets further in order to realize the smooth transfer of scientific knowledge into societal and commercial use, to provide real innovation to the market, and to actively drive the entrepreneurial landscape in Luxembourg. We propose that one additional FTE with the right skills and qualifications will be key in helping both LCSB and UL to realize these objectives.