Molecular, Organellar and Cellular Quality Control in Parkinson’s disease and other Neurodegenerative Diseases

SCHEME: PRIDE

CALL: 2017

DOMAIN: BM - Life Sciences, Biology and Medicine

FIRST NAME: Jens

LAST NAME: Schwamborn

INDUSTRY PARTNERSHIP / PPP: No

INDUSTRY / PPP PARTNER:

HOST INSTITUTION: University of Luxembourg

KEYWORDS: Parkinson's disease, neurodegeneration, induced pluripotent stem cells, in vitro disease modeling, quality control, lysosomal storage, mitochondrial dysfunction, interdisciplinary, autophagy, compound screening, protein misfolding, ageing

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WEBSITE: https://www.uni.lu

Submitted Abstract

Ageing is the most important risk factor for neurodegenerative diseases, such as Parkinson’s disease (PD) and linked to a progressive decline of cellular quality control mechanisms. As for other neurodegenerative diseases, mutations responsible for monogenic forms of PD have been identified, that directly interfere with quality control mechanisms and exemplified pathways of neurodegeneration that directly affect (i) molecular quality control, e.g., via protein misfolding and aggregation or (ii) key instances of organellar quality control, e.g., via impaired mitochondrial clearance. In this PhD training program, using a unique panel of cellular and animal models of PD and related neurodegenerative disorders and applying state-of-the-art computational modeling for the identification of complex regulatory networks underlying cellular transitions, we will dissect mechanisms of molecular, organellar and cellular quality control, and use pharmacological and genetic interventions to develop novel therapeutic approaches for these still incurable neurodegenerative diseases. This interdisciplinary training and research program synergises with current national research programmes on PD and translates into novel advanced diagnostics and treatments for neurodegenerative diseases.

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