Cancer is a disease that requires a multidisciplinary approach to fight it. The study of specific mutations is no longer sufficient to explain the onset of complex pathologies including cancer, diabetes or neurodegenerative diseases. This observation urges to integrate various -omics technologies in order to unravel novel regulatory networks allowing to better understanding the development of these diseases. The merge of high-throughput screening techniques (genomics, transcriptomics, proteomics, metabolomics) with other disciplines including mathematics, bioinformatics and systems biology will allow the discovery of fundamental insights that would remain obscure otherwise. This interdisciplinary approach thus permits to better understand and interpret complex biological phenomena by taking into consideration multiple parameters. Results can then be confirmed by various techniques strengthening the importance of the interdisciplinary OMICS.In this context, the “Cell Signal-omics 2011” conference took place last January (26th- 28th) in Luxembourg. This congress, focusing on “Integrated cellular pathology and Systems Biology of human disease”, gathered together more than 350 international scientists implicated in the different branches of OMICS at the European Congress Center in Luxembourg.