The project will focus on two critical aspects in immunology. First, how inflammation and autoimmune responses are controlled in the body?s periphery, and second, how the same factors contribute to the development of lymphoma. The studies I propose will examine common pathways bridging the fields of inflammation and cancer biology. Protein ubiquitination has emerged as one of the key mechanisms regulating immune homeostasis. The importance of this pathway has been highlighted by recent studies linking the dysregulation of ubiquitination to the onset of autoimmunity and inflammation. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In the last decade, it has become evident that distinct T helper (Th) cell subsets execute specialized immune effector functions in response to specific inflammatory stimuli. My work will concentrate on the roles of Th1, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation. A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.