The Human Proteome Project (HPP) was officially launched withmissions of producing comprehensive human protein map andcreating publicly accessible informational resources for scientificcommunity. By generating an in-depth knowledge of the humanproteome, HPP will have a direct impact on the development ofnew diagnostics and therapeutics, and thus to facilitate theimplementation of the personalized medicine paradigm. Since HPPwill consist of multiple international consortia, and since thenumerous data sets will be integrated into an organized frameworkwhich is chromosome based, one of the critical elements of itssuccess is the standardization of the methods used, and the datagenerated during the program. Under the umbrella of the HPP, weare proposing a project, standardization of proteomics methodsfocusing on quantitative technologies including both samplepreparation and LC-MS procedures, The standardized proceduresand evaluation data will be used in research communities as areference in their benchmarking process. A web-based portal sitewill be created to access, communicate, and evaluate thestandardized methods and materials (standard peptide andproteins) for the proteomics society. The success of this proposedproject will foster a new concept of “benchmark process” indeveloping proteomics laboratories and will certainly facilitate thelarge scale, international collaborations.