Spotlight on Young Researchers: Pit Ullmann

 

Pit Ullmann’s interest in natural sciences was piqued in high school. The Luxembourg national went on to study molecular biology at the University of Innsbruck and then found himself desiring a job that would be both interdisciplinary and diversified – fast forward and Pit is now completing his AFR PhD at the University of Luxembourg, where his research group studies why and how colon cancer develops and spreads.

Deciphering how colon cancer develops and why it spreads

Colon cancer is the second most common cancer in Europe as well as the second most common cause of cancer-related death on the continent[1]. Most deaths from the disease are related to metastasis – when the cancer spreads to other parts of the body.

“In the scope of my PhD project, I was mainly focusing on the effects of hypoxia (i.e. low oxygen concentrations) on the growth behaviour of tumour cells. I was trying to understand if/why/how oxygen availability influences the development of colon cancer.”

In a second part of his PhD project, Pit studied how colon cancer metastasises. In both the first and second part of his project, Pit’s focus was on microRNAs – tiny molecules that regulate gene expression: ”I was trying to understand how they regulate colon cancer initiation and progression, as well as metastatic spreading of the disease”, adding:

“Altogether, my research aims at a better understanding of the disease and the identification of potential molecular targets for the development of novel therapeutic strategies.”

Working in close collaboration with Luxembourgish hospitals

Most research projects related to the medical field rely on patient samples. Pit explains that one of the interesting aspects of his project was working with fresh patient material, such as tumour biopsies or blood samples:

“In order to obtain our research samples, we have to work in close collaboration with different Luxembourgish hospitals and partner institutions, such as the Integrated Biobank of Luxembourg. The use of patient material thereby ensures great proximity to practice and allows us to test our findings in a clinically relevant setting.”

Keeping informed about new developments and communicating your own

When asked what a typical day looks like for him, Pit says that there is no such thing in research, and that any regular tasks change in line with the stage of the project.

He does, however, stress the importance of staying up to date with the latest discoveries in your field – and talking about your own, which he explains is mainly done “at conferences, talks and presentations, teaching lessons, scientific posters and publications, short and long articles, and last but not least writing of a thesis at the end of the PhD project!”

Pit putting cells into a -150°C freezer

A future in research in Luxembourg

Pit is happy he returned to Luxembourg to do complete his studies and to do his PhD – and he will not stop there. Pit has just defended his PhD and is now about to embark on a Postdoc, where he will extend his work to the tumour ‘microenvironment’ – e.g. non-cancerous cells that surround the tumour.

Overall, Pit hopes that his work during his career as a researcher will contribute to a better understanding of colon cancer, and ultimately that this will help bring about new treatments or prevention strategies. And he wants to do it in Luxembourg:

“Being originally from Luxembourg and after having spent a couple of years abroad for my studies, I really enjoy living and working in my home country, close to my friends and family.

“I would like to establish myself here in Luxembourg and help advance the field of biomedical research in our country. I am also convinced that the (biomedical) research activity in Luxembourg has an exciting future ahead – and I would like to contribute to its success.”

Pit also mentions that returning to Luxembourg also brought personal joy in that he fell in love after returning home to Luxembourg: “In terms of unexpected and promising results, the most interesting find that I’ve made during my PhD probably is my life partner – she was also doing a PhD at the University of Luxembourg at the time we met!

[1] http://www.crcprevention.eu/index.php?pg=colorectal-cancer-epidemiology

Published 16 March 2017

Pit Ullmann

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About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the second in a series of around 20 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Paul Hauseux

Paul Hauseux was always interested in science, but only recently settled on the researcher path. Before that, his career ambitions stretched from working in sports or music to teaching science. Some years and a PhD later, the French national has come to Luxembourg for his computational engineering Postdoc in the team of ERC grantee Stéphane Bordas at the University of Luxembourg.

Spotlight on Young Researchers: Amy Parrish

During her Master’s studies, Amy Parrish found her passion for research with a clinical aspect. Having come from London to Luxembourg to pursue her AFR PhD at the Luxembourg Institute of Health (LIH) in the research group of Mahesh Desai, the American national studies the bacteria that inhabit our gut, to shed light on the development of diseases such as Inflammatory Bowel Disease (IBD).

Spotlight on Young Researchers: Yamila Mariel Omar

As part of her Industrial Fellowship – a collaboration between the University of Luxembourg and company Husky – PhD candidate Yamila Mariel Omar helps industry to monetize their proprietary data by means of big data analytics. We speak to the Argentinian national who also became a mother during her PhD.

Spotlight on Young Researchers: German Castignani

After doing his Master’s degree and working in the private sector in Argentina, German Castignani decided to do a research internship in France, which piqued his interest for research. After completing his PhD in wireless networking in France, the Italian-Argentinian national came to Luxembourg, where he added an entrepreneurial perspective to his vehicular telematics research, co-founding the SnT’s first spin-off Motion-S.

Spotlight on Young Researchers: Sumit Gautam

While we frequently hear about new trends in mobile and wireless technologies, challenges remain, such as the need to charge devices on a stationary device. At the SnT at the University of Luxembourg, Postdoc Sumit Gautam works on solving the future information and energy requirements of wireless devices, via radio frequency (RF)-based techniques.

Spotlight on Young Researchers: Eva Lagunas

Eva Lagunas has always been curious about technology, even building her own makeshift smartphone when she was a child. A couple of degrees later, the Spanish national set her sights on coming to Luxembourg, family in tow, to take up a Postdoc position at the University of Luxembourg’s Interdisciplinary Centre for Security, Reliability and Trust (SnT). Now, she feels lucky to spend her time researching satellite communications in the 5G era.

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