The EU Joint Programme – Neurodegenerative Disease Research (JPND) will launch a new cohesive action with the European Commission – a call for “Multinational research projects on Personalised Medicine for Neurodegenerative Diseases”.
Neurodegenerative diseases are debilitating and still largely untreatable conditions. They are characterised by a large variability in their origins, mechanisms and clinical expression. When searching for a medical solution, e.g. a treatment or an optimised approach for care, this large variability constitutes a major hurdle if not controlled. Indeed a treatment addressing one disease pathway may not be useful for all patients experiencing the relevant symptoms. Thus, one of the greatest challenges for treating neurodegenerative diseases is the deciphering of this variability.
JPND has chosen to focus in the area of Precision Medicine, which relates to the targeting of specific elements responsible for pathology in a given individual at a particular point in time. It is an emerging approach for disease prevention, diagnosis and treatment that takes into account individual variability in genes, biological/molecular characteristics together with environmental and lifestyle factors.
The upcoming call for multidisciplinary research proposals conducted by JPND and the European Commission will focus on Precision Medicine in the following research areas:
- Diagnosis (e.g. biomarkers, imaging data, omics approaches, big data analyses)
- Prevention (e.g. biomarkers for studying novel treatments and interventions, co-morbidities, digital technologies, stratification within cohort studies and clinical trials)
- Care (e.g. improvement of social and health care systems, molecular profiling, imaging, lifestyle data)
The following neurodegenerative diseases are included in the call:
- Alzheimer’s disease and other dementias
- Parkinson’s disease and PD‐related disorders
- Prion diseases
- Motor neuron diseases
- Huntington’s disease
- Spinocerebellar ataxia (SCA)
- Spinal muscular atrophy (SMA)
The total made available for this call is 30 MEUR (from all participating countries as well as the European Commission), with each country funding their own national participants in successful collaborative proposals, according to their national budget allocation.
The FNR has allocated 500,000 EUR for this Call, which is expected to fund 1 – 2 projects involving Luxembourg partners.
- The Luxembourg project partner needs to be eligible for FNR funding.
- Pre-proposals must additionally be submitted to the FNR, along with the FNR INTER documents, no later than 5 working days after the JPND deadline. This must be done via the FNR Grant Management System.
This will be a two-step call, expected to be launched in early January 2019, with a likely pre-proposal submission deadline in March 2019. Further details will be provided with the launch of the call.